MS Fore Front Security for SharePoint:

http://www.microsoft.com/forefront/sharepoint/en/us/product-overview.aspx

McAfee:

http://us.trendmicro.com/us/products/enterprise/portalprotect/index.html

But there seems to be a big area that companies are forgetting about, that can effect the stability of MOSS servers and cause a lot of issues that really confuse IT professionals. The OPERATING SYSTEM ANTIVIRUS.

To rule out any interference that the operating system antivirus software might bring to SharePoint's stability, the following exclusions from the antivirus real-time scan are recommended:

Windows 2003 Server

KB822158 - Virus scanning recommendations for computers that are running Windows
Server 2003, Windows 2000, or Windows XP http://support.microsoft.com/kb/822158 

Internet Information Server

• The IIS compression directory (default compression directory is %systemroot%\IIS Temporary Compressed Files)
• %systemroot%\system32\inetsrv folder
• Files that have the .log extension
Refer to the following knowledge base articles for reference:
KB817442 - IIS 6.0: Antivirus Scanning of IIS Compression Directory May Result in 0-Byte File
http://support.microsoft.com/kb/817442
KB821749 - Antivirus software may cause IIS to stop unexpectedly http://support.microsoft.com/kb/821749

SQL Server

• Exclude .MDF, .LDF, .NDF, .TRN, .BAK and .SLS
• Exclude sqlmangr.exe and sqlservr.exe
• SQL folder and databases files (or database file types) from scanning for performance reasons:
KB309422 - Guidelines for choosing antivirus software to run on the computers that are running SQL Server http://support.microsoft.com/kb/309422

WSS 3,0 / MOSS 2007 

• Drive:\Program Files\Microsoft Office Servers\12.0
• Drive:\Program Files\Common Files\Microsoft Shared\web server extensions\12
• Drive:\DOCUME~1\ALLUSE~1\APPLICATION DATA\MICROSOFT\FIREWALL CLIENT\*
• Drive:\WINDOWS\Temp\WebTempDir\*
• Drive:\DOCUMENTS AND SETTINGS\<SPSServiceAccount>\LOCAL SETTINGS\APPLICATION DATA\*
• Drive:\Documents and Settings\\<SPSServiceAccount>\Local Settings\Temp\*
• Drive:\WINDOWS\system32\LogFiles
• W3wp.exe, cbd.exe, cidaemon.exe, owstimer.exe (WSS)
(where Drive: is the drive letter where you installed SharePoint Portal Server)

MOM

·    Drive:\Program Files\Microsoft Operations Manager 2005

If you are using Trend Micro the follow these guide lines:

• Temp folder:  C:\Program Files\Trend Micro\PortalProtect\temp
• Quarantine folder, whose default location is:
Drive:\Program Files\Trend Micro\PortalProtect\Quarantine
• Backup folder, whose default location is:
Drive:\Program Files\Trend Micro\PortalProtect\Backup

The following link will provide you how you can configure MOSS anti-virus, not Operating System Anti-Virus.

http://technet2.microsoft.com/Office/f/?en-us/library/1289e6e2-03e0-4f10-8921-e516187891c61033.mspx

One of my recomendation before logging Microsoft PSS calls is to make sure you have these guidelines applied in your environment, this could save a lot of  time & money with regard to support issues. I hope this helps.

I thought I would add this to the post; the offical KB article associated to "Folders may have to be excluded from antivirus scanning when you use a file-level antivirus program in Windows SharePoint Services 3.0 or in SharePoint Server 2007": http://support.microsoft.com/kb/952167